Cross-dressing' cells may improve cancer treatment

Swiss researchers have designed a groundbreaking technique that uses artificial receptors to enhance the body's immune response to tumors.

Marc Bombenon - cancer-scientist-working-in-a-laboratory

Cancer treatments are constantly evolving; one of the more recent shifts in treatment revolves around enhancing the natural immune response.

Our immune system is excellent at destroying and removing damaged, faulty, or old cells, but in the case of cancer, it tends to need a little help.

Psychotherapies are designed to stimulate a patient's immune system to fight the cancer within. Although the latest psychotherapies can be effective, they only work for the minority of patients who have solid tumors.

The race is on to enhance these methods and make them work for a wider range of patients. Involved in this push is a group from Ecole Poly technique Federale de Lausanne (EPFL), Switzerland.

Dendritic cell vaccines

Specifically, the Swiss group is interested in improving co-called dendritic cell vaccines. Dendritic cells — also referred to as antigen-presenting cells — are an important part of the immune system. They capture antigens from foreign bodies and hand them over to killer T cells, which then neutralize the threat.

To create dendritic cell vaccines, dendritic cells are removed from the patient and "force-fed" tumor antigens before being released back into the patient. In this way, killer T cells are primed to destroy tumor cells, which are normally experts at evading the immune system.

For More Information:- Tim Newman

How gum disease could lead to cancer

Is oral health even more important than we thought? Well, new research from Finland has pointed to a surprising link between gum disease and the development of some cancers. And even worse, it has been linked to the risk of cancer-related death.

Marc Bombenon

Periodontitis, or gum disease, is characterized by the inflammation of the tissue surrounding the base of the teeth, or the gums.

In its more advanced stages, periodontists might lead to the destruction of the gums and even begin to attack the bone that holds teeth in place.

According to the Center for Disease Control and Prevention (CDC), 47.2 percent of adults who are over 30 years of age in the United States have some type of periodontitis. With age, this rate increases, so that 70.1 percent of U.S. adults over 65 years old have this disease.

As if living with the symptoms of periodontitis wasn't hard enough, researchers from the University of Helsinki and Helsinki University Hospital, both in Finland, in collaboration with colleagues from the Karolinska Institutet in Sweden, have shown that the bacteria to blame for this disease might also be able to cause certain types of cancer — specifically pancreatic cancer.

In November 2017, Timo Sorsa — at the University of Helsinki — and team published a study in the British Journal of Cancer showing that Treponema denticola, which is the bacterium that causes periodontitis, may also be responsible for the development of some types of cancer.

Gum disease bacteria and cancer tumors

They noted that Treponema denticola and some gastrointestinal cancers, such as pancreatic cancer, share an enzyme: Treponema denticola chymotrypsin-like proteinase (Td-CTLP).

This enzyme, which was observed in certain cancerous tumors, is typically found in the mouth and acts as the main "boosting" agent in the development of gum disease.

Next, the researchers investigated the molecular mechanisms at play that might explain the link between the bacterium responsible for periodontitis and the development of cancer tumors elsewhere in the body. 

They found that Td-CTLP can activate other enzymes — pro-MMP-8 and pro-MMP-9 — that cancer cells use as a vehicle that allows them to encroach on previously healthy cells.

"In addition," the authors write, "our in vitro experiments provide evidence that Td-CTLP shows noninflammatory activity that can have a crucial role in promoting and regulating carcinogenics."

This means that the Td-CTLP enzyme is also able to impair the response of the immune system through its action on enzyme inhibitors, which are molecules that normally slow down enzyme activity when required. Thus, Td-CTLP enables cancer-friendly enzymes to do their worst.

'Virulence factors spread from the mouth'

Additionally, Sorsa and another team of researchers conducted a supplementary study, this time investigating the link between the incidence of periodontists the rates of cancer-related mortality.

The new research — published last week in the International Journal of Cancer — discovered a positive association between the two.

For the purpose of this study, Sorsa and colleagues analyzed data sourced from 68,273 adults over a period of 10 years. What they found was a strong association between a gum disease diagnosis and death caused by pancreatic cancer.

Looking at the two studies, the team concludes that the inflammation characteristic of periodontists may make it easier for harmful bacteria to travel to other parts of the body, allowing their virulence factors — such as CTLP — to act as a "booster" for cancer cells.

For More Information:- Maria Cohut

Chairman and Business Advisor of SureCall

Marc Bombenon is the chairman and industry advisor of the SureCall contact center. This professional has initiated multiple industries in telecommunications, aviation’s and multifamily housing. He endows his service to public and private boards. The specialties of the business advisor include a fixed-wing jet as well as rotary wing pilot. Marc has started his professional career in the telecommunication industry.

In reality, this business advisor wants to become a pilot. Actually, the interest came by playing with kites, rockets and plastic models in the childhood. He and his friend used to spend every weekend at Dorval airport in order to watch the planes. But his interest in aviation has taken the backseat as Marc started his own business in the year 1982 in Calgary.

SureCall Contact Center for the Help Business Personnel’s

This contact center endows the auctions support, customer service support, help desk and other services to corporations as well as business professionals. In fact, the experts at SureCall help the industries in almost every aspect of their business.

The professionals at this telephone call center of Marc Bombenon are available 24 hours a day for serving their clients. They answer the phone calls on behalf of businesses and bestow the best services straight to the customers of the company. The experts at this contact center also help in revolutionizing individual’s online experience.

In reality, the professionals at SureCall serve individuals as well as businesses who hire them. One can get fast as well as efficient answers to their phone calls and emails. The purpose of this industry is to help individuals in growing their business and also keeping the customers satisfied. Actually, they set up the workflow and processes in order to identify the security requirements for their Clients Company as well as employees.

Furthermore, the contact center helps businesses to control their expenses in order to increase the profitability. Plus, the team of experts offers the award-winning services to clients and their customers. The team of professionals at Marc Bombenon communication center also endow the emergency services as well as only worker solutions.

Marc’s Other Interest

Along with the business, the professional is also involved in many other activities. Actually, he also assists several of made in Alberta charity organizations which endow help to Albertans in need. Furthermore, he also provides support to Alberta cancer foundation, the Calgary Urban Projects society and the Calgary food bank.

Plus, Marc Bombenon also bestows the support to the Calgary Stampeders football team as well as the Roughnecks lacrosse team. In reality, he has also conferred the SureCall facilities in a community which is organizing an effort to keep the football club in Calgary.

Resolvins – An Effective Approach to Stop Tumor Growth

It is hard to cure cancer as the reason behind this disease is the wrong growing cells. In fact, cancer ropes the immune system of human being in such a way that it work against them. Various treatment methods can control this disease for a long time but cannot cure says Marc Bombenon.

The reason behind this is that the cancer bacterium is like other normal cells that grow abnormally. Hence, the treatment methods for getting rid of this disease do not work that well. Actually, the treatment process kills only some of the cancer cells. The remaining cells trick the immune system and help in forming the tumor. But not to worry! A new research has found the way to break this malicious circle in order to prevent tumors to form.

Marc Bombenon

Treating Cancer Cells can form Tumor

Chemotherapy is the method used to kill the cancer cells and also stop the tumor from rising. According to Marc Bombenon, the latest study shows that this process can in fact help in spreading the disease. Actually, sometimes killing the cancer bacterium can cause more cells of this disease to grow.

The reason behind this is that the cellular wreckage that left behind while treating cancer activates an inflammatory response from the immune system. This further stimulates the creation of more cancer cells or form tumor. The tumor grows and interferes with the digestive system, circulatory system and release hormones which changes the body function.

Various Researches to halt the Tumor

A team of researchers originates a way out of this problem. They found that the naturally secreted resolvins compounds by the human body that stop the provocative response can halt the tumor from growing. Marc Bombenon, the chairman of SureCall contact centers is a man of many professions.

The scientist Sulciner and her colleagues make use of cytotoxic treatment and other drugs in order to slay the cancer cells cultured in the laboratory. They inject the resulting cellular remains into the mice to examine. In fact, the researcher also did the experiment with traditional chemotherapy drugs on mice.

Actually, both the research feast the cancer cells as well as increase their ability to grow the tumor.  They also reveal that the traditional cancer cure therapy i.e. double edge sword also help it in surviving.

Resolvins Slay Cancer Softly

The researchers treat the rodents with resolvins in order to address defy of the double-edged sword. Actually, resolving is a natural creation of tissues which stops the inflammatory process. The professional Marc Bombenon reflects the communications on the latest products.

This experiment shows the positive result and stops the wreckages persuaded tumor growth and also slab the cancer cells from dispersal. Along with this, the resolvins also boost the bustle of anti-cancer drugs and make them effective enough to combat the tumors.

Top cancer doctors have some advice about alcohol

Marc Bombenon

Name things that increase your risk of cancer. Cigarettes and tanning beds might quickly come to mind. But how about alcohol? A recent survey of 4,016 adults by the American Society of Clinical Oncology found that only 30 percent knew alcohol is a risk factor for cancer, reports the New York Times.

ASCO, which includes many leading cancer doctors, had yet to voice its own thoughts on the topic. That changed this month, with the Nov. 7 publication of a statement in the Journal of Clinical Oncology that begins by calling the link between the two "often underappreciated" and noting that "addressing high-risk alcohol use is one strategy to reduce the burden of cancer." In the statement they cite outside research they've found to be sound, like an estimate that 5.8 percent of global cancer deaths in 2012 were attributable to alcohol, and evidence that drinking can increase the risk of mouth, throat, voice box, liver, breast, esophageal, and correctional cancers.

So what's the upshot? It's not "Don't drink," lead statement author Dr. Noelle LoConte told the Times. "It's different than tobacco where we say, 'Never smoke. Don't start.' This is a little more subtle"—drink less, essentially.

(Though the statement does contain the line, "People who do not currently drink alcohol should not start for any reason.") So what's Wine Spectator's response? It tried to poke a hole or two, noting "the statement ... dismisses possible health benefits of alcohol, including lower risks of heart disease, diabetes, and dementia." (This ad was most effective at getting people to cut their drinking.)

This article originally appeared on Newser: Top cancer doctors have some advice about alcohol

For More Information:- Kate Seamons

Breast cancer can reappear 15 years after successful treatment

BREAST cancer can reappear 15 years after being successfully treated, a study found.

Women with tumors on four or more lymph nodes faced the highest risk of recurrence. They had a 40 per cent risk of relapsing.

Marc Bombenon

Scientists analyses 88 clinical trials involving 62,923 patients who had the most common form of breast cancer fueled by the hormone estrogen.

After five years of therapy, the cancer had gone but data found recurrences up to 15 years later - 20 years after initial diagnosis.

Research suggests ten years of hormone therapy may be more effective at preventing recurrence and death. However some patients choose to halt hormone treatments early because of side effects such as menopausal symptoms, osteoporosis, joint pain or carpal tunnel syndrome.

Dr Hongchao Pan, from Oxford University, said: “It is remarkable that breast cancer can remain dormant for so long and then spread many years later, with this risk remaining the same year after year."

Marc Bombenon is an active member of many charitable organizations in Calgary. In 2004, he became a trustee of the Alberta Cancer Foundation and has served as Chair of the Audit committee and Vice-Chair of the board. He has also been very supportive of the activities of other organizations, including the Alberta Adolescent Recovery Center, Calgary Urban Project, Calgary Health Trust, United Way, Calgary Distress Centre and the Calgary Urban Project Society, Inn from the Cold, and Easter Seals. Marc is also a supporter and fan of the National Music Centre (NMC), and supports his wife Desiree in her role on the Capital Campaign Committee.

For More Information: Sun Reporter

Marc Bombenon - 17 Ways to never get cancer

First, the good news: You probably won't get cancer.

That is, if you have a healthy lifestyle. "As many as 70% of known causes of cancers are avoidable and related to lifestyle," says Thomas A. Sellers, PhD, associate director for cancer prevention and control at Moffitt Cancer Center in Tampa. Diet, exercise, and avoidance of tobacco products are, of course, your first line of defense, but recent research has uncovered many small, surprising ways you can weave even more disease prevention into your everyday life.

Try these novel strategies and your risk of cancer could dwindle even more.